Sumo 2+3 [3H12] ist ein Gen, das durch das Symbol SUMO3 kodiert wird. Es ist auch bekannt als: Small ubiquitin-related modifier 3; SUMO-3; SMT3 homolog 1; SUMO-2; Ubiquitin-like protein SMT3A; Smt3A; SUMO3; SMT3A; SMT3H1. Sumo 2+3 [3H12] hat eine Masse von 11.64kDa und eine Aminosäurelänge von 103.
Wir bieten 10 antikörper gegen Sumo 2+3 [3H12], aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).
Entrez Zusammenfassung
This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described.
Gewebespezifität
Expressed predominantly in liver.
Sequenzähnlichkeiten
Belongs to the ubiquitin family. SUMO subfamily.
Posttranslationale Modifikation
Polymeric chains can be formed through Lys-11 cross-linking.
Zellort
Cytoplasm. Nucleus. Nucleus > PML body.
